By partnering with Canada’s largest cohort and health databases, CANUE is building an unprecedented capacity to study how these multiple environmental factors are linked to a wide range of health outcomes. This work will enable effective, evidence-based strategies for planning healthy cities and towns, today and in the future. By collaborating with similar initiatives around the world, we are developing standard measures of environmental factors, giving environmental health researchers a remarkable opportunity to uncover how these factors create both positive and negative impacts on our health.