Children’s health is particularly sensitive to the environment. What they are exposed to during early years can have a significant impact on their healthy development. To better understand these health pathways and how to improve children’s health outcomes, the Canadian Institutes of Health Research funded three research projects considering different aspects of child health: obesity, IBD and asthma & COPD. In this webinar, learn what the researchers discovered through their project and what they plan to do next.

About the Projects

The Developmental Origins of Pediatric Obesity and Obesity-Related Complications

This translational project studies clinical populations of pregnant mothers, their children and parallel rodent model systems in order to determine how early life environmental exposures (e.g.- maternal diets, high blood sugars etc.) affect the genes of the children to influence their risk for obesity. We will also determine whether altering the early life environment (e.g.- through diet etc.) modifies disease risk factors in children most susceptible for obesity. The identification of new early life biomarkers of disease could prevent the extensive health and financial burden of obesity.

The diet-microbiota-gut axis in pediatric IBD

This research program investigates the complex interactions among diet, the gut microbiota, and the host. It provides information that may be essential for personalized dietary and microbiota changes required to keep people with inflammatory bowel disease (IBD) in remission. It is well accepted that the gut microbiota plays a crucial role in the digestion of food, particularly plant-derived starches, and the production metabolites essential for human health. The primary objective of the proposed research is to investigate the complex tripartite interactions between the diet, the gut microbiota, and the host. Additionally, this study aims to characterize the role of microbial food-derived metabolites in pediatric IBD. This study will generate the information necessary for developing methods to improve bacterial activities in our intestine as treatment for IBD patients. This research will have important implications for the quality of life of people with IBD everywhere.

Gene and environment effects on lung health and risk for chronic respiratory disease, asthma & COPD

This project studies a group of babies that have been followed since birth, whose families have filled out lots of questions about what they eat, breathe and how often they get sick. These kids and their families have also done breathing tests that measure how well their lungs are doing. From studying all of this information, we believe we can discover what things each person can do to improve their lungs and prevent them from getting chronic breathing problems, making Canada the healthiest place to live.

About the Presenters

The Developmental Origins of Pediatric Obesity and Obesity-Related Complications

Dr. Vern Dolinsky conducts research at the forefront of understanding the underlying mechanisms of gestational diabetes and its impact on the developmental origins of obesity, diabetes, and cardiovascular disorders in youth. His lab employs a cutting-edge combination of experimental animal models, in vivo imaging, and cellular, molecular, biochemical, and “-omic” technologies to uncover new insights into the biological processes that lead to these conditions. These findings have the potential to revolutionize the development of therapies for the treatment of obesity, diabetes, and heart disease. His work is not only advancing our understanding of these conditions, but also pushing the boundaries of what is possible in biomedical research.

The diet-microbiota-gut axis in pediatric IBD

Alain Stintzi, Ph.D. is a professor with the Department of Biochemistry, Microbiology and Immunology, a member of the Ottawa Institute of Systems Biology, and Vice-Dean of Graduate and Postdoctoral Studies at the Faculty of Medicine, University of Ottawa. Dr. Stintzi obtained his Ph.D. in Molecular and Cellular Biology at the Louis-Pasteur University, France (1997). He was subsequently a Postdoctoral fellow at the Department of Chemistry, University of California at Berkeley. In 2000, he was appointed Assistant Professor at the Department of Veterinary Pathobiology, Oklahoma State University. Dr. Stintzi has considerable experience in systems biology approaches to study the role of the gut microbiota in infectious and chronic diseases. Dr. Stintzi has published over 130 articles and book chapters and has contributed to more than 150 scientific and educational conferences.

Gene and environment effects on lung health and risk for chronic respiratory disease, asthma & COPD

Dr. Padmaja Subbarao is a Clinician-Scientist in Paediatric Respiratory Medicine, specializing clinically in severe asthma. Trained in both Epidemiology and infant and preschool lung function, she holds appointments at the University of Toronto in the Departments of Paediatrics, Physiology and in the Dalla Lana School of Public Health.

Dr. Subbarao’s research program focuses on disentangling preschool wheeze heterogeneity to precisely predict who will develop each type of asthma, monitor its progression and discover the risk factors, exposures and underlying biology associated with each asthma subtype. She is the Director of the CHILD cohort study, one of the largest, most intensively characterized asthma birth cohorts in the world. This world-leading study enabled the discovery of the importance of the gut microbiome for the protection against asthma (cited more than 500 times).

This webinar is presented in partnership with the National Collaborating Centre for Environmental Health.

About the Projects

Developing a Framework for Wastewater Reuse in Canada: Using Quantitative Microbial Risk Assessment, Risk Communication, and Community Engagement for Evaluating Water Fit-For-Purpose Reuse

Drinking water treatment and sanitary waste management are considered the most important environmental public health achievements for infectious disease prevention. This project develops a participatory water reuse framework to engender trust in government and utilities to provide safe reuse water that communities seek to have in an equitable way to address Canada’s $90 billion water service infrastructure deficit.

Endocrine Disrupting Chemicals: Towards Responsible Replacements

This research focuses on determining the extent to which our food, drinking water and breast milk contain the chemicals that have emerged as replacements for polybrominated diphenyl ether flame retardants, phthalates and bisphenol A. We will then determine if these new alternatives are safer than the substances that they have replaced.

Climate Change and Indigenous Food System, Food Security, and Food Safety (Climate Change IFS3)

The Climate Change and Indigenous Food System, Food Security, & Food Safety (Climate Change IFS3) has created a multinational intersectoral team to characterize the vulnerability and resilience of Indigenous food systems to climate change to inform, enhance, and expand climate change adaptation interventions and adaptation planning.

About the Speakers

Developing a Framework for Wastewater Reuse in Canada: Using Quantitative Microbial Risk Assessment, Risk Communication, and Community Engagement for Evaluating Water Fit-For-Purpose Reuse

Norman Neumann is a Professor in the School of Public Health at the University of Alberta. His research program focuses on development of novel approaches and tools for detecting, tracking and assessing human health risks associated with biological hazards in the environment (viruses, bacteria, protozoans, prions).

Endocrine Disrupting Chemicals: Towards Responsible Replacements

Barbara Hales is a James McGill Professor in the Department of Pharmacology and Therapeutics at McGill University. Her research is focused on understanding how chemical exposures adversely affect reproduction and development. Projects in her lab, funded by the Canadian Institutes of Health Research, include the effects of house dust mixtures of flame retardants on reproduction and development, the impact of exposure to phthalates and “green” plasticizers on progeny outcome, and approaches towards the responsible replacement of endocrine disrupting chemicals.

Climate Change and Indigenous Food System, Food Security, and Food Safety (Climate Change IFS3)

Sherilee Harper is a Canada Research Chair in Climate Change and Health and an Associate Professor in the School of Public Health at the University of Alberta. Her research investigates associations between weather, environment, and public health in the context of climate change, and she collaborates with partners across sectors to prioritise climate-related health actions, planning, interventions, and research.

The microbiome is the collection of all microbes, such as bacteria, fungi, viruses, and their genes, that naturally live on our bodies and inside us. Although microbes are so small that they require a microscope to see them, they contribute in big ways to human health and wellness. A person’s core microbiome is formed in the first years of life but can change over time in response to different factors including diet, medications, and environmental exposures. The Canadian Institutes of Health Research funded three projects to consider the interaction between the environment and the microbiome and its impact on human health. In this webinar, learn what this research has discovered and where the investigators plan to go next.

About the Projects

Elucidating the Gene-Environment Interactions that drive Autoimmune Disease among South Asian Canadians – The GEMINI Program

The GEMINI project (Generational differences in Environmental exposures caused by Migration: Impact on Incidence of inflammatory disease) studies a growing concern in South Asian Canadian communities – these communities are experiencing an increase in incidences of chronic inflammatory disease upon exposure to the North American environment.

Programmatic research to understand how modifiable environmental factors interact with the genome in the development of asthma

It isn’t clear why some people get asthma and others don’t, but it’s probably due to a combination of environmental and genetic (inherited) factors. The goal of this research program is to understand these environmental and genetic factors that cause asthma. This new understanding is expected to give us better tools to predict who will get asthma and to develop ways to prevent asthma developing in the first place.

The impact of the gut microbiome and environment on the development of colorectal cancer

This team of international recognized researchers investigates the role of bacteria that reside in the gut in the development of colorectal cancer. The previous and proposed research from this team show that gut bacteria is at the root of colorectal cancer; its manipulation of dietary nutrients such as complex carbohydrates and the subsequent impact on metabolic processes within the gut promotes the development of colorectal cancer in mice and humans that are genetically-predisposed to develop this disease. The research has the capacity to develop diagnostics if a specific bacterial species is identified as the causative agent in colorectal cancer. In addition, the research will lead to the development of preventative protocols for colorectal cancer using alterations in diet or specific antibiotics that displace or out-compete “pathogenic” strains.

About the Speakers

Elucidating the Gene-Environment Interactions that drive Autoimmune Disease among South Asian Canadians – The GEMINI Program

Jen Gommerman, PhD, is Professor and Canada Research Chair in Tissue-specific Immunity Department of Immunology, Temerty Faculty of Medicine, University of Toronto. Jen received her Ph.D. (Immunology) at the University of Toronto in 1998. She went on to do a post-doctoral fellowship at Harvard Medical School studying the complement pathway and then joined Biogen Inc. as a Staff Scientist in 2000. During her tenure at Biogen, she became interested in B cells, Multiple Sclerosis and the TNF superfamily of molecules. After 3 years in Industry, she returned to Academia as an Assistant Professor (Immunology) at the University of Toronto in 2003, in 2015 was promoted to full Professor, and in 2020 was awarded a Tier I Canada Research Chair in Tissue Specific Immunity. Jen’s basic research continues to focus on how members of the TNF superfamily of molecules regulate immunity and autoimmunity, particularly in the mucosae. Her team has uncovered a novel gut-brain axis that regulates neuroinflammation. With respect to translational work, Dr. Gommerman has been examining the role of B lymphocytes in Multiple Sclerosis patients and in animal models of MS and how environmental factors shape the microbiome.

Programmatic research to understand how modifiable environmental factors interact with the genome in the development of asthma

Stuart Turvey, MBBS, DPhil, FRCPC is a Professor of Pediatrics at the University of British Columbia where he holds both the Tier 1 Canada Research Chair in Pediatric Precision Health and the Aubrey J. Tingle Professorship in Pediatric Immunology. He is a Pediatric Immunologist and clinician-scientist based at BC Children’s Hospita. Prior to coming to Vancouver, Dr Turvey completed both his Pediatric Residency and Allergy/Immunology Fellowship at Children’s Hospital, Harvard Medical School, Boston. He holds a medical degree (MB BS) from the University of Sydney, Australia and a doctorate (DPhil) in Immunology from Oxford University where he was a Rhodes Scholar. Dr Turvey is a Fellow of the Royal College of Physicians and Surgeons of Canada and a Diplomate of the American Board of Pediatrics.

The impact of the gut microbiome and environment on the development of colorectal cancer

Dr. Alberto Martin is Professor of Immunology at the University of Toronto. His research interests are in adaptive immunity, cancer immunology and B cells. His lab conducts research in three main areas, each of which is supported by external research funding: AID in antibody diversification, The molecular basis for germinal center selection & The molecular mechanisms of cancer development (i.e. specifically colon cancer and lymphoma).