{"id":4181,"date":"2020-04-06T15:43:17","date_gmt":"2020-04-06T15:43:17","guid":{"rendered":"https:\/\/canue.ca\/?p=4181"},"modified":"2020-04-06T15:43:17","modified_gmt":"2020-04-06T15:43:17","slug":"april-6-2020","status":"publish","type":"post","link":"https:\/\/canue.ca\/fr\/april-6-2020\/","title":{"rendered":"April 6 | 2020"},"content":{"rendered":"

Traffic-Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low-Level Ambient Pollution.<\/strong><\/h3>\n

Johnson M, Brook JR, Brook RD, Oiamo TH, Luginaah I, Peters PA, Spence JD.<\/strong><\/p>\n

J Am Heart Assoc.<\/a>\u00a02020 Apr 7;9(7):e013400. Epub 2020 Apr 2. DOI 10.1161\/JAHA.119.013400<\/a><\/p>\n

 <\/p>\n

Abstract<\/strong><\/p>\n

Background:<\/strong><\/p>\n

The association between fine particulate matter and cardiovascular disease has been convincingly demonstrated. The role of traffic-related air pollutants is less clear. To better understand the role of traffic-related air pollutants in cardiovascular disease development, we examined associations between NO2<\/sub>, carotid atherosclerotic plaque, and cardiometabolic disorders associated with cardiovascular disease.<\/p>\n

Methods and Results: <\/strong><\/p>\n

Cross-sectional analyses were conducted among 2227 patients (62.9\u00b113.8\u00a0years; 49.5% women) from the Stroke Prevention and Atherosclerosis Research Centre (SPARC) in London, Ontario, Canada. Total carotid plaque area measured by ultrasound, cardiometabolic disorders, and residential locations were provided by SPARC medical records. Long-term outdoor residential NO2<\/sub>\u00a0concentrations were generated by a land use regression model. Associations between NO2<\/sub>, total carotid plaque area, and cardiometabolic disorders were examined using multiple regression models adjusted for age, sex, smoking, and socioeconomic status. Mean NO2<\/sub>\u00a0was 5.4\u00b11.6\u00a0ppb in London, Ontario. NO2<\/sub>\u00a0was associated with a significant increase in plaque (3.4\u00a0mm2<\/sup>\u00a0total carotid plaque area per 1\u00a0ppb NO2<\/sub>), exhibiting a linear dose-response. NO2<\/sub>\u00a0was also positively associated with triglycerides, total cholesterol, and the ratio of low- to high-density lipoprotein cholesterol (P<\/em><0.05). Diabetes mellitus mediated the relationship between NO2<\/sub>\u00a0and total carotid plaque area (P<\/em><0.05).<\/p>\n

Conclusions: <\/strong><\/p>\n

Our results demonstrate that even low levels of traffic-related air pollutants are linked to atherosclerotic plaque burden, an association that may be partially attributable to pollution-induced diabetes mellitus. Our findings suggest that reducing ambient concentrations in cities with NO2<\/sub>\u00a0below current standards would result in additional health benefits. Given the billions of people exposed to traffic emissions, our study supports the global public health significance of reducing air pollution.<\/p>\n","protected":false},"excerpt":{"rendered":"

Traffic-Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low-Level Ambient Pollution. <\/p>\n

Johnson M, Brook JR, Brook RD, Oiamo TH, Luginaah I, Peters PA, Spence JD.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-4181","post","type-post","status-publish","format-standard","hentry","category-article-de-la-semaine"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t