{"id":4181,"date":"2020-04-06T15:43:17","date_gmt":"2020-04-06T15:43:17","guid":{"rendered":"https:\/\/canue.ca\/?p=4181"},"modified":"2020-04-06T15:43:17","modified_gmt":"2020-04-06T15:43:17","slug":"april-6-2020","status":"publish","type":"post","link":"https:\/\/canue.ca\/fr\/april-6-2020\/","title":{"rendered":"April 6 | 2020"},"content":{"rendered":"<h3><strong>Traffic-Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low-Level Ambient Pollution.<\/strong><\/h3>\n<p><strong>Johnson M, Brook JR, Brook RD, Oiamo TH, Luginaah I, Peters PA, Spence JD.<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32237976\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">J Am Heart Assoc.<\/a>\u00a02020 Apr 7;9(7):e013400. Epub 2020 Apr 2. DOI <a href=\"https:\/\/doi.org\/10.1161\/JAHA.119.013400\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">10.1161\/JAHA.119.013400<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Background:<\/strong><\/p>\n<p>The association between fine particulate matter and cardiovascular disease has been convincingly demonstrated. The role of traffic-related air pollutants is less clear. To better understand the role of traffic-related air pollutants in cardiovascular disease development, we examined associations between NO<sub>2<\/sub>, carotid atherosclerotic plaque, and cardiometabolic disorders associated with cardiovascular disease.<\/p>\n<p><strong>Methods and Results: <\/strong><\/p>\n<p>Cross-sectional analyses were conducted among 2227 patients (62.9\u00b113.8\u00a0years; 49.5% women) from the Stroke Prevention and Atherosclerosis Research Centre (SPARC) in London, Ontario, Canada. Total carotid plaque area measured by ultrasound, cardiometabolic disorders, and residential locations were provided by SPARC medical records. Long-term outdoor residential NO<sub>2<\/sub>\u00a0concentrations were generated by a land use regression model. Associations between NO<sub>2<\/sub>, total carotid plaque area, and cardiometabolic disorders were examined using multiple regression models adjusted for age, sex, smoking, and socioeconomic status. Mean NO<sub>2<\/sub>\u00a0was 5.4\u00b11.6\u00a0ppb in London, Ontario. NO<sub>2<\/sub>\u00a0was associated with a significant increase in plaque (3.4\u00a0mm<sup>2<\/sup>\u00a0total carotid plaque area per 1\u00a0ppb NO<sub>2<\/sub>), exhibiting a linear dose-response. NO<sub>2<\/sub>\u00a0was also positively associated with triglycerides, total cholesterol, and the ratio of low- to high-density lipoprotein cholesterol (<em>P<\/em>&lt;0.05). Diabetes mellitus mediated the relationship between NO<sub>2<\/sub>\u00a0and total carotid plaque area (<em>P<\/em>&lt;0.05).<\/p>\n<p><strong>Conclusions: <\/strong><\/p>\n<p>Our results demonstrate that even low levels of traffic-related air pollutants are linked to atherosclerotic plaque burden, an association that may be partially attributable to pollution-induced diabetes mellitus. Our findings suggest that reducing ambient concentrations in cities with NO<sub>2<\/sub>\u00a0below current standards would result in additional health benefits. Given the billions of people exposed to traffic emissions, our study supports the global public health significance of reducing air pollution.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Traffic-Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low-Level Ambient Pollution.  <\/p>\n<p>Johnson M, Brook JR, Brook RD, Oiamo TH, Luginaah I, Peters PA, Spence JD.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-4181","post","type-post","status-publish","format-standard","hentry","category-article-de-la-semaine"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts\/4181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/comments?post=4181"}],"version-history":[{"count":0,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts\/4181\/revisions"}],"wp:attachment":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/media?parent=4181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/categories?post=4181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/tags?post=4181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}