{"id":3643,"date":"2019-08-06T18:52:59","date_gmt":"2019-08-06T18:52:59","guid":{"rendered":"https:\/\/canue.ca\/?p=3643"},"modified":"2019-08-06T18:52:59","modified_gmt":"2019-08-06T18:52:59","slug":"august-6-2019","status":"publish","type":"post","link":"https:\/\/canue.ca\/fr\/august-6-2019\/","title":{"rendered":"August 6 | 2019"},"content":{"rendered":"

Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures with and without N95-Respirators.<\/strong>\u00a0<\/strong><\/h3>\n

Morishita M, Wang L, Speth K, Zhou N, Bard RL, Li F, Brook JR, Rajagopalan S, Brook RD.<\/strong><\/p>\n

Am J Hypertens.<\/a>\u00a02019 Jul 27. pii: hpz113. [Epub ahead of print] DOI: 10.1093\/ajh\/hpz113<\/a><\/p>\n

Abstract<\/strong><\/p>\n

BACKGROUND:<\/strong><\/p>\n

The risk for cardiovascular events increases within hours of near-roadway exposures. We aimed to determine the traffic-related air pollutants (TRAP) and biological mechanisms involved and if reducing particulate matter<2.5 \u00b5m (PM2.5) inhalation is protective.<\/p>\n

METHODS:<\/strong><\/p>\n

Fifty healthy-adults underwent multiple 2-hour near-roadway exposures (Tuesdays-Fridays) in Ann Arbor during 2 separate weeks (randomized to wear an N95-respirator during one week). Monday both weeks, participants rested 2-hours in an exam room (once wearing an N95-respirator). Brachial blood pressure, aortic hemodynamics and heart rate variability were repeatedly-measured during exposures. Endothelial function (reactive hyperemia index [RHI]) was measured post-exposures (Thursdays). Black carbon (BC), total particle count (PC), PM2.5, noise and temperature were measured throughout exposures.<\/p>\n

RESULTS:<\/strong><\/p>\n

PM2.5 (9.3\u00b17.7 \u00b5g\/m3), BC (1.3\u00b10.6 \u00b5g\/m3), PC (8375\u00b14930 particles\/cm3) and noise (69.2\u00b14.2 dB) were higher (p-values<0.01) and aortic hemodynamic parameters trended worse while near-roadway (p-values<0.15 versus exam room). Other outcomes were unchanged. Aortic hemodynamics trended towards improvements with N95-respirator usage while near-roadway (p-values<0.15 versus no-use), whereas other outcomes remained unaffected. Higher near-roadway PC and BC exposures were associated with increases in aortic augmentation pressures (p-values<0.05) and trends toward lower RHI (p-values<0.2). N95-respirator usage did not mitigate these adverse responses (non-significant pollutant-respirator interactions). Near-roadway outdoor-temperature and noise were also associated with cardiovascular changes.<\/p>\n

CONCLUSIONS:<\/strong><\/p>\n

Exposure to real-world combustion-derived particulates in TRAP, even at relatively-low concentrations, acutely worsened aortic hemodynamics. Our mixed findings regarding the health benefits of wearing N95-respirators support that further studies are needed to validate if they adequately-protect against TRAP given their growing worldwide usage.<\/p>\n","protected":false},"excerpt":{"rendered":"

Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures with and without N95-Respirators.
\nMorishita M, Wang L, Speth K, Zhou N, Bard RL, Li F, Brook JR, Rajagopalan S, Brook RD.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-3643","post","type-post","status-publish","format-standard","hentry","category-article-de-la-semaine"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t