{"id":3643,"date":"2019-08-06T18:52:59","date_gmt":"2019-08-06T18:52:59","guid":{"rendered":"https:\/\/canue.ca\/?p=3643"},"modified":"2019-08-06T18:52:59","modified_gmt":"2019-08-06T18:52:59","slug":"august-6-2019","status":"publish","type":"post","link":"https:\/\/canue.ca\/fr\/august-6-2019\/","title":{"rendered":"August 6 | 2019"},"content":{"rendered":"<h3><strong>Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures with and without N95-Respirators.<\/strong><strong>\u00a0<\/strong><\/h3>\n<p><strong>Morishita M, Wang L, Speth K, Zhou N, Bard RL, Li F, Brook JR, Rajagopalan S, Brook RD.<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31350540\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Am J Hypertens.<\/a>\u00a02019 Jul 27. pii: hpz113. [Epub ahead of print] DOI: <a href=\"https:\/\/doi.org\/10.1093\/ajh\/hpz113\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">10.1093\/ajh\/hpz113<\/a><\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>BACKGROUND:<\/strong><\/p>\n<p>The risk for cardiovascular events increases within hours of near-roadway exposures. We aimed to determine the traffic-related air pollutants (TRAP) and biological mechanisms involved and if reducing particulate matter&lt;2.5 \u00b5m (PM2.5) inhalation is protective.<\/p>\n<p><strong>METHODS:<\/strong><\/p>\n<p>Fifty healthy-adults underwent multiple 2-hour near-roadway exposures (Tuesdays-Fridays) in Ann Arbor during 2 separate weeks (randomized to wear an N95-respirator during one week). Monday both weeks, participants rested 2-hours in an exam room (once wearing an N95-respirator). Brachial blood pressure, aortic hemodynamics and heart rate variability were repeatedly-measured during exposures. Endothelial function (reactive hyperemia index [RHI]) was measured post-exposures (Thursdays). Black carbon (BC), total particle count (PC), PM2.5, noise and temperature were measured throughout exposures.<\/p>\n<p><strong>RESULTS:<\/strong><\/p>\n<p>PM2.5 (9.3\u00b17.7 \u00b5g\/m3), BC (1.3\u00b10.6 \u00b5g\/m3), PC (8375\u00b14930 particles\/cm3) and noise (69.2\u00b14.2 dB) were higher (p-values&lt;0.01) and aortic hemodynamic parameters trended worse while near-roadway (p-values&lt;0.15 versus exam room). Other outcomes were unchanged. Aortic hemodynamics trended towards improvements with N95-respirator usage while near-roadway (p-values&lt;0.15 versus no-use), whereas other outcomes remained unaffected. Higher near-roadway PC and BC exposures were associated with increases in aortic augmentation pressures (p-values&lt;0.05) and trends toward lower RHI (p-values&lt;0.2). N95-respirator usage did not mitigate these adverse responses (non-significant pollutant-respirator interactions). Near-roadway outdoor-temperature and noise were also associated with cardiovascular changes.<\/p>\n<p><strong>CONCLUSIONS:<\/strong><\/p>\n<p>Exposure to real-world combustion-derived particulates in TRAP, even at relatively-low concentrations, acutely worsened aortic hemodynamics. Our mixed findings regarding the health benefits of wearing N95-respirators support that further studies are needed to validate if they adequately-protect against TRAP given their growing worldwide usage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures with and without N95-Respirators.<br \/>\nMorishita M, Wang L, Speth K, Zhou N, Bard RL, Li F, Brook JR, Rajagopalan S, Brook RD.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-3643","post","type-post","status-publish","format-standard","hentry","category-article-de-la-semaine"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts\/3643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/comments?post=3643"}],"version-history":[{"count":0,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/posts\/3643\/revisions"}],"wp:attachment":[{"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/media?parent=3643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/categories?post=3643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/canue.ca\/fr\/wp-json\/wp\/v2\/tags?post=3643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}